F33Application of early sonographic markers of Down syndrome to pregnancies achieved by assisted reproduction techniques

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Validation of correction factors for serum markers for first-trimester Down syndrome screening in singleton pregnancies conceived with assisted reproduction.

OBJECTIVE To validate previously computed correction factors for free β-human chorionic gonadotrophin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) pregnancies with hormone treatment and to determine the effect on false-positive rate (FPR). METHODS Retrospective study on 249 IVF and 250 ICSI cases and 20...

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Down Syndrome Screening in Pregnancies Conceived after Assisted Reproductive Technologies

Over the last three decades, prenatal screening for Down syndrome and other chromosomal abnormalities has become routine during antenatal care. Down syndrome screening has changed from the second to the first trimester of pregnancy because of the higher detection rate and earlier diagnosis. Second-trimester screening, based on the combination of maternal serum human chorionic gonadotropin (hCG)...

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First trimester biochemical screening for Down's syndrome in singleton pregnancies conceived by assisted reproduction.

BACKGROUND Serum biochemical markers [free betahCG (fbetahCG); pregnancy-associated plasma protein-A (PAPP-A)] used in first trimester Down's syndrome screening have not been fully investigated in pregnancies achieved by assisted reproduction techniques. We present data on pregnancies conceived by all types of assisted reproduction techniques, including pregnancies following ovum donation (OD) ...

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Isolated sonographic markers for detection of fetal Down syndrome in the second trimester of pregnancy.

OBJECTIVE To determine whether sonographic "markers" are associated with fetal Down syndrome during the second trimester and to estimate the degree of risk of individual markers using likelihood ratios. METHODS Second-trimester (14-20 weeks) sonographic findings in 186 fetuses with trisomy 21 were compared with a control group of 8728 consecutive control fetuses. Six markers were evaluated: n...

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ژورنال

عنوان ژورنال: Ultrasound in Obstetrics and Gynecology

سال: 2000

ISSN: 0960-7692

DOI: 10.1046/j.1469-0705.2000.00015-1-33.x